Send to

Choose Destination
Nat Rev Neurosci. 2006 Mar;7(3):194-206.

Astrocyte dysfunction in neurological disorders: a molecular perspective.

Author information

Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany.


Recent work on glial cell physiology has revealed that glial cells, and astrocytes in particular, are much more actively involved in brain information processing than previously thought. This finding has stimulated the view that the active brain should no longer be regarded solely as a network of neuronal contacts, but instead as a circuit of integrated, interactive neurons and glial cells. Consequently, glial cells could also have as yet unexpected roles in the diseased brain. An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center