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Br J Cancer. 2006 Mar 27;94(6):776-80.

MicroRNAs in cell proliferation, cell death, and tumorigenesis.

Author information

1
Program in Human Genetics and Molecular Biology, The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 460C, Baltimore, MD 21205, USA.

Abstract

MicroRNAs (miRNAs) are a recently discovered class of approximately 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.

PMID:
16495913
PMCID:
PMC2361377
DOI:
10.1038/sj.bjc.6603023
[Indexed for MEDLINE]
Free PMC Article

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