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Infect Immun. 2006 Mar;74(3):1973-6.

Requirement of norD for Brucella suis virulence in a murine model of in vitro and in vivo infection.

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1
INSERM U431, Université Montpellier II, Place E. Bataillon, CC100, 34095 Montpellier Cedex 05, France.

Abstract

A mutant of Brucella suis bearing a Tn5 insertion in norD, the last gene of the operon norEFCBQD, encoding nitric oxide reductase, was unable to survive under anaerobic denitrifying conditions. The norD strain exhibited attenuated multiplication within nitric oxide-producing murine macrophages and rapid elimination in mice, hence demonstrating that norD is essential for Brucella virulence.

PMID:
16495577
PMCID:
PMC1418625
DOI:
10.1128/IAI.74.3.1973-1976.2006
[Indexed for MEDLINE]
Free PMC Article
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