Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge

Sylvia R Treviño; Amy R Permenter; Marilyn J England; Narayanan Parthasarathy; Paul H Gibbs; David M Waag; Tran C Chanh

doi:10.1128/IAI.74.3.1958-1961.2006

Monoclonal antibodies passively protect BALB/c mice against Burkholderia mallei aerosol challenge

Infect Immun. 2006 Mar;74(3):1958-61. doi: 10.1128/IAI.74.3.1958-1961.2006.

Authors

Sylvia R Treviño¹, Amy R Permenter, Marilyn J England, Narayanan Parthasarathy, Paul H Gibbs, David M Waag, Tran C Chanh

Affiliation

¹ Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21702-5001, USA.

Abstract

Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.

MeSH terms

Aerosols
Animals
Antibodies, Bacterial / administration & dosage*
Antibodies, Bacterial / immunology
Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal / immunology
Burkholderia mallei / immunology*
Glanders / immunology
Glanders / mortality
Glanders / prevention & control*
Mice
Mice, Inbred BALB C

Substances

Aerosols
Antibodies, Bacterial
Antibodies, Monoclonal