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Infect Immun. 2006 Mar;74(3):1944-8.

A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.

Author information

1
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, MD 21702-5011, USA. david.waag@amedd.army.mil

Abstract

Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.

PMID:
16495571
PMCID:
PMC1418646
DOI:
10.1128/IAI.74.3.1944-1948.2006
[Indexed for MEDLINE]
Free PMC Article

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