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Antimicrob Agents Chemother. 2006 Mar;50(3):1104-7.

NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus.

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1
Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston Massachusetts 02114-2696, USA.

Abstract

NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.

PMID:
16495280
PMCID:
PMC1426456
DOI:
10.1128/AAC.50.3.1104-1107.2006
[Indexed for MEDLINE]
Free PMC Article
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