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Antimicrob Agents Chemother. 2006 Mar;50(3):1096-9.

Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole.

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  • 1Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.

Abstract

In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.

PMID:
16495278
PMCID:
PMC1426442
DOI:
10.1128/AAC.50.3.1096-1099.2006
[PubMed - indexed for MEDLINE]
Free PMC Article
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