Format

Send to

Choose Destination
FEBS Lett. 2006 Mar 6;580(6):1625-30. Epub 2006 Feb 17.

Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline.

Author information

1
Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North 5301, New Zealand.

Abstract

Paspaline belongs to a large, structurally and functionally diverse group of indole-diterpenes synthesized by filamentous fungi. However, the identity of the gene products required for the biosynthesis of paspaline, a key intermediate for the synthesis of paxilline and other indole-diterpenes, is not known. Transfer of constructs containing different pax gene combinations into a paxilline negative deletion derivative of Penicillium paxilli demonstrated that just four proteins, PaxG, a geranylgeranyl diphosphate synthase, PaxM, a FAD-dependent monooxygenase, PaxB, a putative membrane protein, and PaxC, a prenyl transferase, are required for the biosynthesis of paspaline.

PMID:
16494875
DOI:
10.1016/j.febslet.2006.02.008
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center