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FEBS Lett. 2006 Mar 6;580(6):1625-30. Epub 2006 Feb 17.

Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline.

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Institute of Molecular Biosciences, Massey University, Private Bag 11222, Palmerston North 5301, New Zealand.


Paspaline belongs to a large, structurally and functionally diverse group of indole-diterpenes synthesized by filamentous fungi. However, the identity of the gene products required for the biosynthesis of paspaline, a key intermediate for the synthesis of paxilline and other indole-diterpenes, is not known. Transfer of constructs containing different pax gene combinations into a paxilline negative deletion derivative of Penicillium paxilli demonstrated that just four proteins, PaxG, a geranylgeranyl diphosphate synthase, PaxM, a FAD-dependent monooxygenase, PaxB, a putative membrane protein, and PaxC, a prenyl transferase, are required for the biosynthesis of paspaline.

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