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Emerg Infect Dis. 2006 Feb;12(2):198-203.

Detecting hepatitis B surface antigen mutants.

Author information

1
Abbott Laboratories, Abbott Park, Illinois 60064-6015, USA. paul.coleman@abbott.com

Abstract

Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations that occur within the immunodominant epitopes of hepatitis B surface antigen (HBsAg) allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is key to establishing an appropriate testing algorithm for hepatitis B virus detection programs.

PMID:
16494742
PMCID:
PMC3293431
DOI:
10.3201/eid1203.050038
[Indexed for MEDLINE]
Free PMC Article

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