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Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Dec;19(23):1088-91.

[Research of a new kind of biological response modifier to anti-laryngocarcinoma].

[Article in Chinese]

Author information

1
Department of Immunology, Medical School of Xi'an Jiaotong University, Xi'an, 710061, China.

Abstract

OBJECTIVE:

To find a new kind of biological response modifier to anti-laryngocarcinoma through studying the efficiency of resveratrol.

METHOD:

To detect the growth inhibiting rate of Hep-2 exposed to resveratrol with MTT colorimetry and to analyze the apoptosis and cell cycle of Hep-2 with flow cytometry. As having formed the model of laryngocarcinoma, quite a few indicatrixes including the content changes of IL-2, IL-8,TGF-beta1 and VEGF were detected.

RESULT:

Resveratrol could induce apoptosis of Hep-2 in time-concentration-dependent manners showing obvious cell cycle blocking of G0/G1 and apoptotic peak. Furthermore, resveratrol improved remarkably the growth condition of mice planted with Hep-2 while enhancing their immunological function.

CONCLUSION:

As a kind of biological response modifier, resveratrol could strengthen anti-tumor immunoresponse, accommodating lymphocyte to secrete cytokine, through which it exerted the efficiency of anti-laryngocarcinoma.

PMID:
16494014
[Indexed for MEDLINE]

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