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Am J Hematol. 2006 Mar;81(3):210-1.

Recognition and management of methemoglobinemia and hemolysis in a G6PD-deficient patient on experimental anticancer drug Triapine.

Author information

1
Division of Hematology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Abstract

We report occurrence of severe methemoglobinemia in a patient on novel experimental anti-cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high-risk populations prior to commencement of Triapine therapy.

PMID:
16493607
DOI:
10.1002/ajh.20547
[Indexed for MEDLINE]
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