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Nat Rev Mol Cell Biol. 2006 Feb;7(2):143-7. doi: 10.1038/nrm1787.

The eureka enzyme: the discovery of DNA polymerase.

Author information

1
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 79503-9072, USA. errol.friedberg@utsouthwestern.edu

Abstract

The identification and partial purification by Arthur Kornberg and his colleagues in 1956 of an enzyme - DNA polymerase I of Escherichia coli - that catalysed the stable incorporation of deoxyribonucleotides into DNA in vitro came as a surprise. At the time, most scientists in the field believed that DNA synthesis was too complicated to be accurately reflected outside the living cell.

PMID:
16493419
DOI:
10.1038/nrm1787
[Indexed for MEDLINE]
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