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Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42.

Complex networks orchestrate epithelial-mesenchymal transitions.

Author information

1
Centre National de la Recherche Scientifique (CNRS) Unité Mixte Recherche (UMR) 144 and Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France. Jean-Paul.Thiery@curie.fr

Abstract

Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.

PMID:
16493418
DOI:
10.1038/nrm1835
[Indexed for MEDLINE]

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