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Nat Rev Mol Cell Biol. 2006 Jan;7(1):45-53.

Making digit patterns in the vertebrate limb.

Author information

1
Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. c.a.tickle@dundee.ac.uk

Abstract

The vertebrate limb has been a premier model for studying pattern formation - a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models.

PMID:
16493412
DOI:
10.1038/nrm1830
[Indexed for MEDLINE]

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