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Community Genet. 2006;9(1):55-61.

PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships.

Author information

1
Institute of Medical Informatics and Statistics, Christian Albrechts University, Kiel, Germany. krawczak@medinfo.uni-kiel.de

Abstract

OBJECTIVE:

Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers.

DESIGN:

Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit.

RESULTS:

PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases.

CONCLUSION:

PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition.

PMID:
16490960
DOI:
10.1159/000090694
[Indexed for MEDLINE]
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