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Am J Surg. 2006 Mar;191(3):433-6.

Positron-emission tomography as a prognostic tool for early-stage lung cancer.

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1
Department of Surgery, Division of Thoracic Surgery, William Beaumont Hospital, 3601 W Thirteen Mile Road, Royal Oak, MI 48073, USA.

Abstract

BACKGROUND:

Positron-emission tomography (PET) shows tissue metabolic activity in the form of the standard uptake value (SUV). This study examines the prognostic value of the SUV for early-stage lung cancer.

METHODS:

A retrospective review of 187 patients undergoing PET for potential lung cancer. Data collected included patient demographics, tumor pathology, and survival information. Data were correlated with PET results to determine if a prognostic relationship exists.

RESULTS:

The sensitivity and specificity of PET for detecting malignant lesions were 98% and 24%. Malignant lesions had a higher SUV than benign lesions (5.9 +/- 6.2 versus 2.2 +/- 1.8, P < .0001). The average SUV of well-differentiated tumors was 2.6 +/- 3.1 versus 5.9 +/- 5.5 for other tumors (P = .010). There was a strong correlation between tumor stage and SUV (analysis of variance, P < .0001). There was no difference in tumor SUV for survivors versus nonsurvivors.

CONCLUSIONS:

The SUV correlates with prognostic indicators, such as tumor stage and grade. The SUV alone was not an independent predictor of survival.

PMID:
16490562
DOI:
10.1016/j.amjsurg.2005.10.052
[Indexed for MEDLINE]
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