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Am J Ophthalmol. 2006 Mar;141(3):584-5.

Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritis.

Author information

1
Proctor Foundation, Department of Ophthalmology, University of California-San Francisco, 95 Kirkham Street, San Francisco, CA 94143, USA. nisha@stanfordalumni.org

Abstract

PURPOSE:

To compare polymerase chain reaction (PCR) results to presumptive clinical diagnosis in patients with vitritis.

DESIGN:

Retrospective review of PCR laboratory records from vitreous samples.

METHODS:

Fifty consecutive laboratory records of vitreous samples sent for PCR testing were reviewed. Three reviewers with uveitis training ranked the clinical suspicion of a specific diagnosis using a classification system (scale of 1 to 4) and were masked to the PCR results.

RESULTS:

The degree of clinical suspicion of a particular diagnosis was significantly associated with a positive PCR result (P = .048). Higher clinical suspicion was significantly more associated with a positive PCR result compared with cases with lower clinical suspicion (P = .01).

CONCLUSIONS:

If the clinical suspicion of a specific diagnosis is low, the PCR for any infectious etiology is unlikely to be positive.

PMID:
16490520
DOI:
10.1016/j.ajo.2005.10.011
[Indexed for MEDLINE]

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