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Acta Pharmacol Sin. 2006 Mar;27(3):259-72.

Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.

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1
Pediatric Research and Electron Microscopy Unit, Ruth and Baruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.

Abstract

With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.

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