Send to

Choose Destination
See comment in PubMed Commons below
Acta Pharmacol Sin. 2006 Mar;27(3):259-72.

Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.

Author information

Pediatric Research and Electron Microscopy Unit, Ruth and Baruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.


With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center