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Nat Rev Microbiol. 2006 Mar;4(3):183-92.

N6-methyl-adenine: an epigenetic signal for DNA-protein interactions.

Author information

1
INSERM U318, CHU Michallon, Université Joseph Fourier, 38043 Grenoble, France. didier.wion@ujf-grenoble.fr

Abstract

N(6)-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most bacterial DNA adenine methyltransferases are part of restriction-modification systems. Certain groups of Proteobacteria also harbour solitary DNA adenine methyltransferases that provide signals for DNA-protein interactions. In gamma-proteobacteria, Dam methylation regulates chromosome replication, nucleoid segregation, DNA repair, transposition of insertion elements and transcription of specific genes. In Salmonella, Haemophilus, Yersinia and Vibrio species and in pathogenic Escherichia coli, Dam methylation is required for virulence. In alpha-proteobacteria, CcrM methylation regulates the cell cycle in Caulobacter, Rhizobium and Agrobacterium, and has a role in Brucella abortus infection.

PMID:
16489347
PMCID:
PMC2755769
DOI:
10.1038/nrmicro1350
[Indexed for MEDLINE]
Free PMC Article

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