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Curr Opin Cell Biol. 2006 Apr;18(2):168-78. Epub 2006 Feb 20.

Actin dynamics at the Golgi complex in mammalian cells.

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Departament de Biologia Cel.lular i Anatomia Patològica, Facultat de Medicina and Instituts de Nanociències i Nanotecnologia (IN(2)UB) and d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, E-08036 Barcelona, Spain.


Secretion and endocytosis are highly dynamic processes that are sensitive to external stimuli. Thus, in multicellular organisms, different cell types utilize specialised pathways of intracellular membrane traffic to facilitate specific physiological functions. In addition to the complex internal molecular factors that govern sorting functions and fission or fusion of transport carriers, the actin cytoskeleton plays an important role in both the endocytic and secretory pathways. The interaction between the actin cytoskeleton and membrane trafficking is not restricted to transport processes: it also appears to be directly involved in the biogenesis of Golgi-derived transport carriers (budding and fission processes) and in the maintenance of the unique flat shape of Golgi cisternae.

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