Format

Send to

Choose Destination
Curr Opin Cell Biol. 2006 Apr;18(2):192-8. Epub 2006 Feb 17.

CDK activation by non-cyclin proteins.

Author information

1
CNIO (Spanish National Cancer Center), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.

Abstract

Progression through the cell cycle is regulated by cyclin-dependent kinases (CDKs), which associate with activating partners, named cyclins, to phosphorylate substrates efficiently. Cyclins are periodically synthesized and degraded during the cell cycle, playing a key role in the precise activation and inactivation of CDKs. However, CDKs can also be activated by other proteins, which lack sequence similarity to cyclins. These include the RINGO/Speedy proteins, which were originally identified as regulators of the meiotic cell cycle in Xenopus oocytes. Recently, five different mammalian RINGO/Speedy family members have been reported, all of which can bind to and directly activate Cdk1 and Cdk2.

PMID:
16488127
DOI:
10.1016/j.ceb.2006.01.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center