Format

Send to

Choose Destination
Proc Soc Exp Biol Med. 1991 Jul;197(3):242-8.

Receptors that activate platelets.

Author information

1
Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

Abstract

This review highlights the increasing knowledge of the biochemistry, pathology, and cell and molecular biology of platelet receptors. A receptor for ADP has been identified using the affinity label FSBA as aggregin, a 100-kDa membrane protein responsible for shape change, aggregation, and exposure of fibrinogen binding sites. A variety of putative receptors for collagen have been described, with GPIa/IIa and GPIV receiving the most attention recently. A thromboxane A2 receptor has been identified using receptor antagonists and photoaffinity labels. The alpha 2-adrenergic receptor has been cloned and expressed. The platelet thrombin receptor has been tentatively identified as GPIb. Following binding of thrombin to this receptor, activation of calpain occurs, with cleavage of aggregin leading to exposure of GPIIb/III alpha and platelet aggregation. Isolation, expression, or both of the ADP, collagen, and thrombin receptors as single gene products of the human platelet responsible for activation, and more complete understanding of stimulus-response coupling, should allow for greater specificity of drugs with selective therapeutic actions.

PMID:
1648741
DOI:
10.3181/00379727-197-43251
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center