Format

Send to

Choose Destination
Phys Rev Lett. 2006 Jan 27;96(3):038101. Epub 2006 Jan 23.

Functional subconformations in protein folding: evidence from single-channel experiments.

Author information

1
Laboratory of Physical and Structural Biology, NICHD, NIH, Bethesda, Maryland 20892-0924, USA.

Abstract

We study fluctuations in ion conductance and enzymatic rates of the sugar-specific channel-forming membrane protein, Maltoporin, at the single-molecule level. Specifically, we analyze time-persistent deviations in the transport parameters of individual channels from the multichannel averages and discuss our findings in the context of static disorder in protein folding. We show that the disorder responsible for variations in ion conductance does not affect sugar binding, suggesting that Maltoporin can exist in a wide set of fully functional, yet distinctly different, subconformations.

PMID:
16486775
DOI:
10.1103/PhysRevLett.96.038101
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Physical Society
Loading ...
Support Center