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Nat Rev Drug Discov. 2006 Jan;5(1):37-50. doi: 10.1038/nrd1930.

Epigenetic therapy of cancer: past, present and future.

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1
USC/Norris Comprehensive Cancer Center, Department of Urology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, California 90089, USA.

Erratum in

  • Nat Rev Drug Discov. 2006 Feb;5(2):121.

Abstract

The initiation and progression of cancer is controlled by both genetic and epigenetic events. Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations are potentially reversible, allowing the malignant cell population to revert to a more normal state. With the advent of numerous drugs that target specific enzymes involved in the epigenetic regulation of gene expression, the utilization of epigenetic targets is emerging as an effective and valuable approach to chemotherapy as well as chemoprevention of cancer.

PMID:
16485345
DOI:
10.1038/nrd1930
[Indexed for MEDLINE]

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