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Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3693-7. Epub 2006 Feb 16.

Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.

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1
Human Neurogenetics Laboratory, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Abstract

Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice.

PMID:
16484369
PMCID:
PMC1450143
DOI:
10.1073/pnas.0511189103
[Indexed for MEDLINE]
Free PMC Article
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