Format

Send to

Choose Destination
See comment in PubMed Commons below
Best Pract Res Clin Rheumatol. 2006 Feb;20(1):99-115.

Nutraceuticals: do they work and when should we use them?

Author information

1
Tufts-New England Medical Center, Boston, MA 02111, USA. tmcalindon@tufts-nemc.org

Abstract

There are numerous biological mechanisms by which nutritional factors might be expected to exert favorable influences on pathophysiological processes in osteoarthritis. Such processes include oxidative damage, cartilage matrix degradation and repair, and chondrocyte function and responses in adjacent bone. Micronutrients for which preliminary evidence of benefit exists include vitamin C and vitamin D. In addition, numerous nutraceuticals that may influence osteoarthritis pathophysiology--including glucosamine, chondroitin, S-adenosylmethionine, ginger and avocado/soybean unsaponifiables--have been tested in clinical trials. These products are safe and well tolerated, but interpretation of the collective results is hampered by heterogeneity of the studies, inconsistent results, and the conundrum of how to reconcile an apparent structural benefit with absence or modest effect on symptoms.

PMID:
16483910
DOI:
10.1016/j.berh.2005.09.002
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center