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PLoS Genet. 2006 Feb;2(2):e21. Epub 2006 Feb 17.

Comparative genomics of emerging human ehrlichiosis agents.

Author information

1
The Institute for Genomic Research, Rockville, Maryland, USA. jdunning@tigr.org

Erratum in

  • PLoS Genet. 2006 Dec;2(12):e213. Eisen, Jonathan [corrected to Eisen, Jonathan A].

Abstract

Anaplasma (formerly Ehrlichia) phagocytophilum, Ehrlichia chaffeensis, and Neorickettsia (formerly Ehrlichia) sennetsu are intracellular vector-borne pathogens that cause human ehrlichiosis, an emerging infectious disease. We present the complete genome sequences of these organisms along with comparisons to other organisms in the Rickettsiales order. Ehrlichia spp. and Anaplasma spp. display a unique large expansion of immunodominant outer membrane proteins facilitating antigenic variation. All Rickettsiales have a diminished ability to synthesize amino acids compared to their closest free-living relatives. Unlike members of the Rickettsiaceae family, these pathogenic Anaplasmataceae are capable of making all major vitamins, cofactors, and nucleotides, which could confer a beneficial role in the invertebrate vector or the vertebrate host. Further analysis identified proteins potentially involved in vacuole confinement of the Anaplasmataceae, a life cycle involving a hematophagous vector, vertebrate pathogenesis, human pathogenesis, and lack of transovarial transmission. These discoveries provide significant insights into the biology of these obligate intracellular pathogens.

PMID:
16482227
PMCID:
PMC1366493
DOI:
10.1371/journal.pgen.0020021
[Indexed for MEDLINE]
Free PMC Article

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