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Nat Rev Mol Cell Biol. 2006 Mar;7(3):225-30.

A visual approach to proteomics.

Author information

1
Max Planck Institute for Biochemistry, Department of Structural Biology, Am Klopferspitz 18, D-82152 Martinsried, Germany.

Abstract

Cryo-electron tomography is an emerging imaging technique that has unique potential for molecular cell biology. At the present resolution of 4-5 nm, large supramolecular structures can be studied in unperturbed cellular environments and, in the future, it will become possible to map molecular landscapes inside cells in a more comprehensive manner. 'Visual proteomics' aims to complement and extend mass-spectrometry-based inventories, and to provide a quantitative description of the macromolecular interactions that underlie cellular functions.

PMID:
16482091
DOI:
10.1038/nrm1861
[Indexed for MEDLINE]

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