Format

Send to

Choose Destination
Ann N Y Acad Sci. 2005 Dec;1063:161-6.

TLR2 is necessary to inflammatory response in Coxiella burnetii infection.

Author information

1
Unité des Rickerrsies, CNRS UMR 6020, Université de Méditerranée, 13005 Marseille, France.

Abstract

The resolution of Q fever, a zoonosis caused by Coxiella burnetii, depends on efficient innate and adaptive immune responses. Such responses are influenced by Toll-like receptors (TLRs). TLR4 is involved only in part in immune responses against C. burnetii, suggesting a role for TLR2. We investigated C. burnetii infection in wild-type and TLR2(-/-) mice. C. burnetii organisms were similarly eliminated by wild-type and TLR2(-/-) mice. In contrast, the formation of granulomas, a marker for efficient cell-mediated immunity, was markedly impaired. These results show that TLR2 is required for inflammatory and immune response to C. burnetii, but is dispensable for bacterial clearance.

PMID:
16481508
DOI:
10.1196/annals.1355.025
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center