Format

Send to

Choose Destination
See comment in PubMed Commons below
Genes Dev. 2006 Feb 15;20(4):417-22.

Drosophila lacking microRNA miR-278 are defective in energy homeostasis.

Author information

1
European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Erratum in

  • Genes Dev. 2006 Apr 1;20(7):913. Maitra, Sushmita [added].

Abstract

The mechanisms that control energy homeostasis and tissue growth during development are closely linked through the insulin signal transduction pathway. Changes in the level of insulin and other hormones reflect the nutritional status of the animal to control circulating sugar levels and fat metabolism. Systemic defects in insulin responsiveness can lead to elevated circulating glucose levels and fat accumulation. Here we present evidence that the microRNA miR-278 plays a role in the control of energy homeostasis in Drosophila. miR-278 mutants have elevated insulin production and are correspondingly lean. Despite the elevated insulin levels, miR-278 mutants have elevated circulating sugar, mobilized from adipose-tissue glycogen stores. We provide evidence that miR-278 mutants are insulin resistant and that miR-278 acts through regulation of the expanded transcript.

PMID:
16481470
PMCID:
PMC1369043
DOI:
10.1101/gad.374406
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center