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Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. Epub 2006 Feb 14.

Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.

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1
NPS-Pharmaceuticals, 383 Colorow Drive, Salt Lake City, UT 84108, USA.

Abstract

Structure-activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.

PMID:
16481165
DOI:
10.1016/j.bmcl.2006.01.100
[Indexed for MEDLINE]
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