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Bioorg Med Chem Lett. 2006 May 1;16(9):2492-5. Epub 2006 Feb 15.

Investigation of the mechanism of action of 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans by flow cytometry.

Author information

1
Department of Biological and Medical Sciences, School of Pharmacy, Charles University, Heyrovského 1203, CZ-500 05 Hradec Králové, Czech Republic. luisandrevale.silva@faf.cuni.cz

Abstract

The mechanism of action of the antifungal agent 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans was investigated by flow cytometry, using propidium iodide, DiBAC4(3), and FUN-1 as the fluorescent dyes. A related but less active agent, together with amphotericin B and fluconazole, was tested in parallel for comparison of the results. The incrustoporine derivative was found to have a potent fungicidal activity on C. albicans, resulting in damage of cell membrane.

PMID:
16480875
DOI:
10.1016/j.bmcl.2006.01.094
[Indexed for MEDLINE]

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