Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities

Sunil K Chattopadhyay; Anirban Pal; Prakas R Maulik; Tanpreet Kaur; Ankur Garg; Suman Preet S Khanuja

doi:10.1016/j.bmcl.2006.01.077

Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities

Bioorg Med Chem Lett. 2006 May 1;16(9):2446-9. doi: 10.1016/j.bmcl.2006.01.077. Epub 2006 Feb 9.

Authors

Sunil K Chattopadhyay¹, Anirban Pal, Prakas R Maulik, Tanpreet Kaur, Ankur Garg, Suman Preet S Khanuja

Affiliation

¹ Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 221005, India. chattsk@yahoo.com

PMID: 16480866
DOI: 10.1016/j.bmcl.2006.01.077

Abstract

The needles of Taxus wallichiana gave a taxoid 1-hydroxy- 2-deacetoxy-5-decinnamoyl-taxinine j, whose structure has been established by spectroscopic data and confirmed by X-ray crystallography. The taxoid possesses significant cytotoxic and immunomodulatory activity.

Publication types

Comparative Study

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Concanavalin A / pharmacology
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Immunologic Factors / chemistry
Immunologic Factors / isolation & purification
Immunologic Factors / pharmacology*
Lymphocytes / drug effects
Models, Molecular
Molecular Conformation
Taxoids / chemistry
Taxoids / isolation & purification
Taxoids / pharmacology*
Taxus / chemistry*
Vinblastine / pharmacology
Vincristine / pharmacology

Substances

1-hydroxy- 2-deacetoxy-5-decinnamoyl-taxinine j
Antineoplastic Agents
Immunologic Factors
Taxoids
Concanavalin A
Vincristine
Vinblastine