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Vaccine. 2006 Apr 5;24(15):2799-802. Epub 2006 Jan 18.

Do recommended high-risk adults benefit from a first influenza vaccination?

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Julius Center for Health Sciences and Primary Health Care, University Medical Center Utrecht, HP 6.139, P.O. Box 85060, 3508 AB Utrecht, The Netherlands.


It is unknown whether a first influenza vaccination protects high-risk adults from severe morbidity and mortality during influenza epidemics. As part of the PRISMA nested case-control study, we aimed to evaluate the effectiveness of first-time and repeat influenza vaccinations in adult persons recommended for vaccination aged between 18 and 64 years during the 1999-2000 influenza A epidemic. After adjustments, 69% of hospitalizations for acute respiratory or cardiovascular disease or death were prevented in first-time vaccinees (95% percent confidence interval [95% CI]: 8-90%). The corresponding figure in persons who were vaccinated before was 85% (95% CI: 36-96%). Adult persons with high-risk medical conditions can substantially benefit from a first and repeat influenza vaccination prior to an epidemic.

[Indexed for MEDLINE]

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