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Helix-loop-helix proteins in lymphocyte lineage determination.

Author information

1
Department of Pathology, University of Chicago, IL 60637, USA. bkee@bsd.uchicago.edu

Abstract

The cells of the lymphoid system develop from multipotent hematopoietic stem cells through a series of intermediate progenitors with progressively restricted developmental options. Commitment to a given lymphoid lineage appears to be controlled by numerous transcriptional regulatory proteins that activate lineage-specific gene expression programs and extinguish expression of lineage-inappropriate genes. In this review I discuss the function of transcription factors belonging to the helix-loop-helix protein family in the control of lymphoid cell fate decisions. A model of lymphocyte lineage determination based on the antagonistic activity of transcriptional activating and repressing helix-loop-helix proteins is presented.

PMID:
16480037
[Indexed for MEDLINE]

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