Format

Send to

Choose Destination
See comment in PubMed Commons below
Sleep. 2005 Jun;28(6):673-6.

Dose-response effects of tiagabine on the sleep of older adults.

Author information

  • 1Sleep Medicine & Research Center, St. John's Mercy Medical Center, St. Luke 's Hospital, St. Louis, MO, USA. walsjk@stlo.smhs.com

Abstract

STUDY OBJECTIVES:

To evaluate the dose- response effects of tiagabine on sleep and safety measures in healthy older adults.

DESIGN:

Randomized, double-blind, Latin-square design.

SETTING:

Sleep laboratory.

PARTICIPANTS:

Twenty-four healthy older adults (11 men, 13 women; mean age 68.0 +/- 6.2 years)

INTERVENTIONS:

Tiagabine 2, 4, or 8 mg, or placebo, each given on two consecutive nights.

MEASUREMENTS AND RESULTS:

Polysomnography revealed that compared with placebo, tiagabine 4 mg increased total sleep time, reduced wake after sleep onset, and increased minutes of slow-wave sleep. Tiagabine 8 mg decreased wake after sleep onset, increased slow-wave sleep, and improved a sleep-continuity index. No differences were seen between the 2-mg dose and placebo. Subjective ratings indicated fewer awakenings with the 8-mg dose. Central nervous system adverse events were somewhat higher in the 8-mg condition only. Measures of morning performance were minimally affected.

CONCLUSIONS:

Research with tiagabine at dosages of 8 mg or less appears warranted in elderly clinical populations.

PMID:
16477953
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center