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Neurology. 2006 Feb 14;66(3):415-7.

Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population.

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  • 1Department of Neuroscience, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.


An association between mutations in the glucocerebrosidase (GBA) gene and Parkinson disease (PD) was recently reported in Ashkenazi Jews. The authors screened a series of 311 Norwegian patients with PD and 474 controls for 2 common functional mutations of the GBA protein, N370S and L444P. Seven patients (2.3%) and 8 controls (1.7%) carried a mutant GBA allele (p = 0.58). This study does not indicate increased susceptibility to PD in GBA mutations carriers in Norway.

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