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Neurology. 2006 Feb 14;66(3):349-53.

Oral contraceptives and increased headache prevalence: the Head-HUNT Study.

Author information

1
Department of Neuroscience, Norwegian National Headache Centre, St. Olav's University Hospital, Trondheim, Norway. k.aegidius@dadlnet.dk

Abstract

OBJECTIVE:

To examine the prevalence of headache and migraine among women using oral contraceptives (OCs) in a large, cross-sectional population-based study.

METHODS:

In the Nord-Tr√łndelag Health Study in Norway 1995-1997 (HUNT 2), 27,700 (60%) out of 46,506 invited women responded to headache questions (Head-HUNT). Among 14,353 premenopausal women, 13,944 (97%) responded to questions regarding use of contraceptives.

RESULTS:

There was a significant association between headache and reported use of estrogen-containing OCs in premenopausal women, both for migraine (OR = 1.4, 95% CI = 1.2 to 1.7) and for non-migrainous headache (OR = 1.2, 95% CI = 1.0 to 1.4). A significant dose relationship between headache and the amount of estrogen in the OCs could not be demonstrated. No significant association between headache and OCs containing only gestagen was found.

CONCLUSION:

Headache, especially migraine, was more likely among premenopausal women using oral contraceptives containing estrogen.

[Indexed for MEDLINE]

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