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J Exp Med. 2006 Feb 20;203(2):305-10. Epub 2006 Feb 13.

T-independent type II immune responses generate memory B cells.

Author information

1
Laboratory of Molecular Immunology and 2Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.

Abstract

Unlike T-dependent immune responses against protein antigens, T-independent responses against polysaccharides confer long-lasting humoral immunity in the absence of recall responses and are not known to generate memory B cells. Here we report that polysaccharide antigens elicit memory B cells that are phenotypically distinct from those elicited by protein antigens. Furthermore, memory B cell responses against polysaccharides are regulated by antigen-specific immunoglobulin G antibodies. As the generation and regulation of immunologic memory is central to vaccination, our findings help explain the mode of action of the few existing polysaccharide vaccines and provide a rationale for a wider application of polysaccharide-based strategies in vaccination.

PMID:
16476769
PMCID:
PMC2118207
DOI:
10.1084/jem.20052036
[Indexed for MEDLINE]
Free PMC Article

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