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Nat Neurosci. 2006 Mar;9(3):311-3. Epub 2006 Feb 12.

Respiratory rhythm generation during gasping depends on persistent sodium current.

Author information

1
Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK. Julian.F.R.Paton@Bristol.ac.uk

Abstract

In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.

PMID:
16474390
DOI:
10.1038/nn1650
[Indexed for MEDLINE]

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