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Immunity. 2006 Feb;24(2):127-9.

CD14: chaperone or matchmaker?

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  • 1University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.


In this issue of Immunity, describe a physical and functional relationship between Toll-like receptor 3 (TLR3) and the pattern recognition protein CD14. In the presence of CD14, TLR3-mediated signal transduction events are amplified.

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