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Cancer Lett. 2006 Feb 20;233(1):1-9.

Ether à go-go potassium channels and cancer.

Author information

1
Pharmacology Section, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, México, DF 07360, México. fcamacho@cinvestav.mx

Abstract

Ion channels play important roles in health and disease. In the last few years, an interesting relationship between potassium channels and cancer has evolved. Especially, members of the ether à go-go (EAG) potassium channels family have gained interest as research tools for detection and therapy of different cancers. This review will summarize most of the findings relating EAG channels and cancer, focusing on mRNA expression in tissues, oncogenic properties, modulation and pharmacology. Plausible scenarios on the cellular mechanisms of EAG oncogenicity will be discussed.

PMID:
16473665
DOI:
10.1016/j.canlet.2005.02.016
[Indexed for MEDLINE]

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