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Trends Microbiol. 2006 Mar;14(3):101-4. Epub 2006 Feb 10.

Genomic dissection of microbial pathogenesis in cultured Drosophila cells.

Author information

1
D333 Fairchild Building, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305-5124, USA.

Abstract

Recent RNA interference screens that were performed at a genome-wide level have identified host factors that are important for the growth of Listeria monocytogenes in cultured cells from the fruit fly Drosophila melanogaster. The screens identified genes that are involved in phagocytosis but did not detect genes known to be involved in immune signaling pathways. These studies provide a foundation for the identification of host factors and virulence mechanisms.

PMID:
16473012
DOI:
10.1016/j.tim.2006.01.008
[Indexed for MEDLINE]

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