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Methods Enzymol. 2006;406:500-11.

Activation of Rho and Rac by Wnt/frizzled signaling.

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1
Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Piscataway, USA.

Abstract

Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes by means of several distinct pathways. Wnt/Fz activation of the small GTPases Rho and Rac has emerged as a key mechanism that regulates cell polarity and movements during vertebrate gastrulation. In this chapter, we describe biochemical assays for the detection of Wnt/Fz activation of Rho and Rac in both mammalian cells and Xenopus embryo explants.

PMID:
16472682
DOI:
10.1016/S0076-6879(06)06038-1
[Indexed for MEDLINE]
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