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Eur J Cancer. 1991;27(5):613-5.

131I-rose bengal therapy in hepatoblastoma patients.

Author information

1
Werkgroep Kindertumoren, Emma Kinderziekenhuis/het kinder AMC, Amsterdam, The Netherlands.

Abstract

If conventional treatment modalities have failed in hepatoblastoma patients and no distant metastases can be demonstrated therapy with radionuclide agents can be considered. In 6 patients diagnostic technetium-99m (99mTc)-disofenin and two iodine-131 (131I)-rose bengal scans were made. 2 patients demonstrated specific uptake of disofenin. One of these had a positive scintigram with radiolabelled rose bengal. This patient was subsequently treated with 1.1 GBq 131I-rose bengal. No toxicity was observed. A clear decrease in the level of alpha-fetoprotein indicated a response and demonstrated that this radiopharmaceutical can be used for tumour targeted radiation therapy in selected patients with therapy resistant tumours.

PMID:
1647184
[Indexed for MEDLINE]

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