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Pediatr Blood Cancer. 2006 Jun;46(7):811-4.

A second leiomyosarcoma in the urinary bladder of a child with a history of retinoblastoma 12 years following partial cystectomy.

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1
Department of Urology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. benjamin.brucker@uphs.upenn.edu

Abstract

This case describes a twin with bilateral retinoblastoma who developed leiomyosarcoma of the bladder at age 17 and again at 39. At 17-years of age she was diagnosed with a leiomyosarcoma of the bladder after presenting with recurrent urinary tract infections, hematuria, and dysuria. She was treated with partial cystectomy. After a 12-year disease-free interval, she was diagnosed with a second leiomyosarcoma of the bladder. This case supports the relationship between the genetic form of retinoblastoma and leiomyosarcoma and illustrates the necessity for extensive follow-up and well-defined treatment of secondary neoplasms.

PMID:
16470582
DOI:
10.1002/pbc.20506
[Indexed for MEDLINE]
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