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Cell. 2006 Feb 10;124(3):459-61.

Rejuvenating exhausted T cells during chronic viral infection.

Author information

1
Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto, 606-8501, Japan.

Abstract

In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.

PMID:
16469690
DOI:
10.1016/j.cell.2006.01.022
[Indexed for MEDLINE]
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