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Breast Cancer Res. 2006;8(1):102. Epub 2006 Jan 16.

Recent translational research: oncogene discovery by insertional mutagenesis gets a new boost.

Author information

1
Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. j.hilkens@nki.nl

Abstract

Knowledge of the genes and genetic pathways involved in onco-genesis is essential if we are to identify novel targets for cancer therapy. Insertional mutagenesis in mouse models is among the most efficient tools to detect novel cancer genes. Retrovirus-mediated insertional mutagenesis received a tremendous boost by the availability of the mouse genome sequence and new PCR methods. Application of such advances were limited to lympho-magenesis but are now also being applied to mammary tumourigenesis. Novel transposons that allow insertional mutagenesis studies to be conducted in tumors of any mouse tissue may give cancer gene discovery a further boost.

PMID:
16469121
PMCID:
PMC1413991
DOI:
10.1186/bcr1376
[Indexed for MEDLINE]
Free PMC Article

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