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Nat Rev Cancer. 2006 Mar;6(3):193-203.

Infection, immune responses and the aetiology of childhood leukaemia.

Author information

1
The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom. mel.greaves@icr.ac.uk

Abstract

Childhood leukaemia is the principal subtype of paediatric cancer and, despite success in treatment, its causes remain enigmatic. A plethora of candidate environmental exposures have been proposed, but most lack a biological rationale or consistent epidemiological evidence. Although there might not be a single or exclusive cause, an abnormal immune response to common infection(s) has emerged as a plausible aetiological mechanism.

PMID:
16467884
DOI:
10.1038/nrc1816
[Indexed for MEDLINE]
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