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Int J Pediatr Otorhinolaryngol. 2006 Jul;70(7):1231-4. Epub 2006 Feb 8.

Effects of sevoflurane and TIVA with propofol on middle ear pressure.

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University of Abant Izzet Baysal, Duzce Faculty of Medicine, Department of Otorhinolaryngology, Head and Neck Surgery, D├╝zce, Turkey.



To evaluate the effects of sevoflurane and TIVA with propofol on middle ear pressure and to show the importance of anesthesia without using any inhalational agents during middle ear surgery.


A prospective, randomized controlled clinical study.


In this study, 25 male children that were scheduled for circumcision were randomised into two groups. Group I (n=13) received TIVA with propofol and group II (n=12) received sevoflurane. Baseline tympanometry reading was performed on each ear just before anesthesia. The next tympanometry reading was taken 10min after applying the laryngeal mask. Data were analysed by Mann-Whitney U (between groups) and Wilcoxon tests (within groups).


Mean MEP values in 26 ears of 13 boys in group I did not show any significant difference before and after the anesthesia with propofol (p>0.05). In group II mean MEP values in 24 ears of 12 boys showed a significant increase after the anesthesia with sevoflurane (p<0.001). No significant difference was found between the MEP values of the two groups before the anesthesia (p>0.05), and MEP values measured during the anesthesia were significantly higher in group II (p=0.007).


Sevoflurane may increase the middle ear pressure and TIVA with propofol may be used in middle ear operations more safely than sevoflurane.

[Indexed for MEDLINE]

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